Which statement most accurately describes the differences between respiration and fermentation? Fermentation uses a single substrate as an electron donor and acceptor while respiration uses different substrates. There is no difference between fermentation and respiration. Fermentation uses oxidative phosphorylation for ATP synthesis, respiration uses substrate-level phosphorylation. Respiration uses NADH as an electron carrier, fermentation does not. Respiration uses a single substrate as an electron donor and acceptor while fermentation uses different substrates.